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From the liner notes

Shock jock Grant Mazzy (Stephen McHattie) has, once again, been kicked-off the big city airwaves and now the only job he can get is the early morning show at CLSY Radio in Pontypool - which broadcasts from the basement of the small town's only church.

What begins as another boring day of school bus cancellations - due to yet another massive snow storm - quickly turns deadly. Bizarre reports start piling in of people developing strange speech patterns and evoking horrendous acts of violence. But there's nothing coming in on the news wires. So... is this really happening?

Before long, Grant and the small staff at CLSY (Lisa Houle & Georgina Reilly) find themselves trapped in the radio station as they discover that this insane behavior taking over the town is caused by a deadly virus being spread through the English language itself. Do they stay on the air in the hopes of being rescued or, are they in fact providing the virus with its ultimate leap over the airwaves and into the world?

Based on the acclaimed novel Pontypool Changes Everything by author Tony Burgess (who adapted his own work for the screenplay), Bruce McDonald's newest film is a highly original, darkly funny and delightfully twisted slice of zombie horror that Entertainment Weekly calls a "gory little tour de force - like 28 Days Later as written by linguist Noam Chomsky."