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From the liner notes

Teknolust is a futuristic comedy from director Lynn Hershman Leeson puts a funny spin on recent advancements in science and technology, namely cloning. When bio–geneticist Rosetta Stone (Tilda Swinton) has a major breakthrough and writes a paper about it, her colleagues suspect that she has already tried out her theories in real–life experiments. Unbeknownst to them, Rosetta has created a formula in her computer that combines DNA and software to make the perfect being: part–robot, part–human. She has produced three female test subjects: Ruby, Olive, and Marine (all played by Swinton) who live in the refurbished and fully computer–and–video–equipped basement of her apartment.

Her clones keep her company, entertain her, and listen to her problems. Their only flaw is that they need a chemical found in sperm to survive, so Ruby is programmed to seduce human men and share the sperm with the other two. Trouble starts when Ruby transmits a computer virus to the men she seduces, crashing their "hard drives". The problem is exacerbated when Ruby falls in love with her neighbor, Sandy (Jeremy Davies). When a private detective, Dirty Dick (Karen Black), is hired by one of Rosetta's coworkers to learn the truth about her research, it becomes almost impossible to keep the clones a secret, especially as they develop their own personalities, self–will, and curiosity about the world.