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From the liner notes

Resurrection. After enduring unspeakable torture, Dean escapes from Hell, rescued by an all-powerful creature he's never seen before -– an Angel -– a warrior of God who recruits Sam and Dean into Heaven's battle against Hell. And there are whispers that a certain fallen angel will soon be freed from his prison deep in Hell: Lucifer. If Sam and Dean can't stop it –- if Lucifer walks free -– he'll bring on the Apocalypse. Meanwhile, the Winchester Brothers reunite and hit the road, battling the supernatural wherever they go. They encounter demons, spirits, Dracula himself and even a drunk, heavily armed 7-foot-tall teddy bear. All the while, the ultimate war draws them into its horror throughout this enthralling 22-Episode Season Four. Caught between Heaven and Hell, between God and the Devil, the Winchester brothers must battle for the future of humankind.