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From the liner notes

Another witty and humane ode to male bonding, Looking for Kitty tells the story of Abe (Krumholtz), an upstate New York high school baseball coach, who wakes up to discover that his beautiful wife Kitty has disappeared. When someone sends Abe a photo from a newspaper showing a rock star and his entourage, including a woman who could be Kitty, Abe heads to NYC and hires a private detective to find her. The P.I. in quiestion is Jack (Burns), a loner ex-cop who is burying himself in his work to avoid dealing with the loss of his own wife. Facing eviction from his apartment, Abe's case is an offer Jack can't refuse and a chance to finally put to rest his own grieving by reuniting Abe and Kitty. What emerges from this investigation changes both of their lives forever.