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From the liner notes

Bill Denny (George Segal) and Charlie Walters (Elliott Gould) are two compulsive gamblers with nothing in common except incredibly bad luck. But after a chance meeting at an LA card parlor, these two losers find that together, they make an unbeatable team. Embarking on a once-in-a-lifetime winning streak, Bill and Charlie bet their way from the tacky racetracks and bars of Los Angeles to the plush casino tables of Reno, where they end up staking their good fortune on a "friendly" little game of poker with the legendary world champion, Amarillo Slim. A high-rolling comedy about two friends with an uncontrollable urge to score.